For an oocyte to become ready for fertilization and progress into an embryo, the ideal set of genes must be turned on. Namekawa suspected this pre-programming of your oocyte genome happens in several stages — the very first one commencing round the time a woman is born. He believed that chromatin remodeling proteins did Significantly of this perform, by shifting spools all around.
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This protein may “create and retain the chromatin condition,” states Namekawa — trying to keep the spools in position as well as the oocytes genetically primed because the mouse matures.
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